Research Specialist A/B

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Research Specialist A/B

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Posted Job Title
Research Specialist A/B

Job Profile Title
Research Specialist A

Job Description Summary

Job Description

The George and Simpkins laboratory in the Ovarian Cancer Research Center is looking for a Research Specialist A/B in the lab -particularly with cell and tissue culture and some basic laboratory techniques.Our research focuses on identifying novel targets and therapeutic strategies for ovarian cancer with the ultimate goal to bring them to the clinic for women with ovarian cancer. Our laboratory has developed novel experimental models such as primary cells, patient-derived organoids, and patient-derived xenografts from ovarian tumors that have been characterized genomically and proteomically serving as excellent platforms to study drug resistance. We are looking for a highly motivated, dedicated and enthusiastic individual that is excited about doing research focused on development of therapeutic strategies for ovarian and endometrial cancer by testing of these drugs in in vitro and in vivo models. The Research Specialist will be closely working with Dr. George and other members of the Simpkins lab including research technicians, post-doctoral fellows, and research associates on publication-generating projects. The work will involve the use of cell culture and molecular biology as well as cutting-edge techniques such as survival surgery with orthotopic transplant of patient tumor in order to create PDX mouse models of ovarian and endometrial cancer. S/he will be working in an environment that is team oriented, where creativity, enthusiasm and dedicated effort are highly rewarded.

The Research Specialist will work on a project related to ovarian and endometrial cancer biology with the ultimate goal of developing novel therapeutics for these diseases. The Research Specialists duties will primarily consist of managing multiple cell lines and performing standard molecular biology/biochemical techniques with minimal supervision. They will also assist with managing the mouse colony and patient-derived xenograft studies including drug treatment via oral gavage, surgical procedures, tumor measurement, necropsy and biobanking, and data base entry.In addition to maintaining laboratory records and attending lab meetings, s/he will be responsible for some general laboratory duties. Should the need arise (rarely), this position also may involve work on weekends and evenings.

The primary Role of the Research Specialist A will be:

  • Cellculture including established cell lines, primary cancer cells, patient-derived organoids culture
  • Perform cytotoxicity assays to evaluate drugs in vitro.

  • Study drugs mechanism by western blot, flow cytometry, immunofluorescence and other assays under the supervision of senior scientists in the lab.

  • Analyze and organize data, present data to the lab and to collaborators.

  • Assist with managing of mouse colony, care for mice, administer the drugs via oral gavage (training will be provided) and dosing scheduling.

  • Assist with surgical procedures to develop patient-derived xenografts (PDX), measure the tumor size in mice using palpation and ultrasound (training will be provided).

  • Necropsy and bio-bank the tissue samples (training will be provided)

  • Assist with processing of formalin-fixed paraffin-embedded tissue samples.

  • Attend the lab meetings .

  • S/he will be also responsible for general laboratory duties.

  • Occasionally may have to work on weekends and evenings as project needs require, flexibility with hours is required. Multi-tasking is important.

    Research Specialist B: will have the duties outlined above for a Research Specialist A, with the additional expectation that s(he) will show a higher degree of independence, including the ability to design and troubleshoot experiments with greater autonomy and interpret study results with a lesser degree of input from supervisor(s).

    *Position is contingent upon funding.*

    QUALIFICATIONS: RS-A Bachelor's degree with 0-1 years of experience in laboratory benchwork or an equivalent combination of education and experience required. Experience with cell culture, molecular and cellular biology is preferred. Experience in working with mice, drug administration via oral gavage and survival surgeries is preferred. Should be organized, detail-oriented, able to maintain organized laboratory data, work well with others and is a team player.

    RS-B Bachelor's degree with 1-3 years of experience in laboratory benchwork and pre-clinical study methodologies or an equivalent combination of education and experience required.. Must have experience working with cell culture and in vitro assays. Experience in handling mice, drug administration via oral gavage and survival surgeries is preferred. Experience with necropsy and tissue banking is preferred. Experience ingrowing human primary cells is preferred. Should be organized, detail-oriented, able to maintain organized laboratory data, work well with others and is a team player.

    Job Location - City, State
    Philadelphia, Pennsylvania
    Research Specialist B

    Department / School
    Perelman School of Medicine

    Pay Range
    $36,368.00 - $50,522.66
    Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.

    Affirmative Action Statement
    Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

    Special Requirements
    Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

    University Benefits
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    • Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
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