Research Specialist (Translational Medicine and Human Genetics)

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Research Specialist (Translational Medicine and Human Genetics)

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Employers By State in 2021.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

COVID-19 vaccination is a requirement for all positions at the University of Pennsylvania. New hires are expected to be fully vaccinated before beginning work at the University. For more information about Penn's vaccine requirements and the use of Penn Open Pass, visit the Penn COVID-19 Response website for the latest information.

Posted Job Title
Research Specialist (Translational Medicine and Human Genetics)

Job Profile Title
Research Specialist A

Job Description Summary
We are seeking a talented and motivated scientist to participate in exciting team-oriented research investigating the function of novel genes/pathways associated with insulin resistance and type 2 diabetes (identified through human genetic analyses).

Job Description

At the outset, you will develop and validate primary and iPSC models of insulin responsive cell types including hepatocytes, adipocytes and muscle. Using these models, you will then study T2D-associated genes and variants by applying a variety of techniques including CRISPR/Cas9 genome editing, gene expression profiling, protein signaling, genomic studies and functional assays. There will be ample opportunity to interact with our collaborators who are performing complementary experiments using in vivo mouse models and computational biologists who are identifying candidate T2D genes using bioinformatics approaches. You will also have some effort in generating iPSC-derived cell types for our collaborators on the project. This is an exciting opportunity to work with a highly talented team that will potentially lead to multiple publications.

Duties:

Research Specialist A

Designs and plan for experiments

Perform experiments in a timely manner; troubleshoot experiments as necessary

Analyze data, keep lab notebook and prepare presentations

Perform additional duties as assigned

Research Specialist B

Designs and plan for experiments

Perform experiments in a timely manner; troubleshoot experiments as necessary

Analyze data, keep lab notebook and prepare presentations

Present results, help prepare manuscript for publications and keep up with relevant literature

Perform additional duties as assigned

Research Specialist C

Designs and plan for experiments

Perform experiments in a timely manner; troubleshoot experiments as necessary

Analyze data, keep lab notebook and prepare presentations

Present results, prepare manuscript for publications and keep up with relevant literature

Prepare short term project plans

Prepare longer- term project plans

Perform additional duties as assigned

Research Specialist D

Designs and plan for experiments

Perform experiments in a timely manner; troubleshoot experiments as necessary

Analyze data, keep lab notebook and prepare presentations

Present results, prepare manuscript for publications and keep up with relevant literature

Prepare short term project plans

Prepare longer- term project plans

Train junior staff, postdocs and students

Perform additional duties as assigned

***Position contingent upon funding***

Qualifications:

All positions:

Must have strong background in molecular biology techniques including restriction enzyme digestion, PCR, qRT-PCR; proficient in nucleic acid analysis software tools for PCR primer design and manipulation of nucleic acid sequences; experience with CRISPR/Cas9 gene editing in cell lines or animals highly desirable

Experience (in laboratory setting, not in classroom) in mammalian cell culture and Fluorescence Activated Cell Sorting (FACS) required; experience with hESC/hiPSC culture highly desirable

Must have excellent written/verbal communication and organizational skills

Must be proficient with Microsoft Office and Photoshop software tools

Research Specialist A: Bachelor's degree in the biological sciences and 0-1 year of experience or an equivalent combination of education and experience required. Some relevant hands-on laboratory experience preferred.

Research Specialist B: Bachelor's degree in the biological sciences and at least 1-2 years of post-degree relevant hands-on laboratory experience or an equivalent combination of education and experience required.

Research Specialist C: Bachelor's degree in the biological sciences and at least 3 to 5 years of post-degree relevant hands-on laboratory experience or an equivalent combination of education and experience required.

Research Specialist D: Master's degree in the biological sciences and at least 3 to 5 years of post-degree relevant hands-on laboratory experience or an equivalent combination of education and experience required. PhD degree preferred in the biological sciences with at least one first-author published work.

Working Conditions
Office, Library, Computer Room; Requires extensive safety

Physical Effort
Typically sitting at a desk or table; Occasional lifting 25 lb. or less

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$35,568.00 - $50,256.00

Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits
  • Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
  • Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
  • Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
  • Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
  • Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
  • Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
  • Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
  • University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
  • Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  • Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  • Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
  • Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.



To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay

To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Perelman-Center-for-Adv-Medicine/Research-Specialist--Translational-Medicine-and-Human-Genetics-_JR00049679-1

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